## Archive for December, 2021

### Resampling Approach to Power Analysis

A coauthor and I are doing power analyses based on a pilot test and we quickly realized that it’s really hard to calculate a power analysis for anything much more exotic than a t-test of means. As I usually do when there’s no obvious solution, I decided to just brute force it with a Monte Carlo approach.

The algorithm is as follows:

2. Draw a sample with replacement of the target sample size `n` and do this `trials` times
3. Run the estimation with each of these resampled datasets and see if enough of them achieve significance (with conventional power and alpha this means 80% have p<.05)

In theory, this approach should allow a power analysis for any estimator, no matter how strange. I was really excited about this and figured we could get a methods piece out of it until my coauthor pointed out Green and MacLeod beat us to it. Nonetheless, I figured it’s still worth a blogpost in case you want to do something that doesn’t fit within the lme4 package, around which Green and MacLeod’s simr package wraps the above algorithm. For instance, as seen below, I show how you can do a power analysis for a stratified sample.

## Import pre-test data

In a real workflow you would just use some minor variation on `pilot <- read_csv("pilot.csv")`. But as an illustration, we can assume a pilot study with a binary treatment, a binary DV, and n=6. Let us assume that 1/3 of the control group are positive for the outcome but 2/3 of the treatment group. Note that a real pilot should be bigger – I certainly wouldn’t trust a pilot with n=6.

``````treatment <- c(0,0,0,1,1,1)
outcome <- c(0,0,1,0,1,1)
pilot <- as.data.frame(cbind(treatment,outcome))``````

I suggest selecting just the variables you need to save memory given that you’ll be making many copies of the data. In this case it’s superfluous as there are no other variables, but I’m including it here to illustrate the workflow.

```pilot_small <- pilot %>% select(treatment,outcome)
```

## Display observed results

As a first step, do the analysis on the pilot data itself. This gives you a good baseline and also helps you see what the estimation object looks like. (Unfortunately this varies considerably for different estimation functions).

``````est_emp <- glm(outcome ~ treatment, data = pilot, family = "binomial") %>% summary()
z_emp <- est_emp[["coefficients"]][,3]
est_emp``````
``````##
## Call:
## glm(formula = outcome ~ treatment, family = "binomial", data = pilot)
##
## Deviance Residuals:
##       1        2        3        4        5        6
## -0.9005  -0.9005   1.4823  -1.4823   0.9005   0.9005
##
## Coefficients:
##             Estimate Std. Error z value Pr(>|z|)
## (Intercept)  -0.6931     1.2247  -0.566    0.571
## treatment     1.3863     1.7321   0.800    0.423
##
## (Dispersion parameter for binomial family taken to be 1)
##
##     Null deviance: 8.3178  on 5  degrees of freedom
## Residual deviance: 7.6382  on 4  degrees of freedom
## AIC: 11.638
##
## Number of Fisher Scoring iterations: 4``````

Note that we are most interested in the t or z column. In the case of glm, this is the third column of the coefficient object but for other estimators it may be a different column or you may have to create it manually by dividing the estimates column by the standard deviation column.

Now you need need to see how the z column appears when conceptualized as a vector. Look at the values and see the corresponding places in the table. I wrapped it in `as.vector()` because some estimators give `z` as a matrix.

``as.vector(z_emp)``
``##  -0.5659524  0.8003776``

In this case, we can see that `z_emp` is z for the intercept and `z_emp` is z for the treatment effect. Obviously the latter is more interesting.

## Set range of assumptions for resamples

Now we need to set a range of assumptions for the resampling.

`trials` is the number of times you want to test each sample size. Higher values for `trials` are slower but make the results more reliable. I suggest starting with 100 or 1000 for exploratory purposes and then going to 10,000 once you’re pretty sure you have a good value and want to confirm it. The arithmetic is much simpler if you stick with powers of ten.

`nrange` is a vector of values you want to test out. Note that the z value for your pilot gives you a hint. If it’s about 2, you should try values similar to those in the pilot. If it’s much smaller than 2, you should try values much bigger.

``````trials <- 1000 # how many resamples per sample size
nrange <- c(50,60,70,80,90,100) # values of sample size to test``````

## Set up resampled data, do the regressions, and store the results

This is the main part of the script.

It creates the resampled datasets in a list called `dflist`. The list is initialized empty and dataframes are stored in the list as they are generated.

Store z scores and sample size in matrix `results`.

``````dflist <- list()
k <- 1 # this object keeps track of which row of the results object to write to
results <- matrix(nrow = length(nrange)*trials, ncol=3) %>% data.frame() #adjust ncol value to be length(as.vector(z_emp))+1
colnames(results) <- c('int','treatment','n') # replace the vector with names for as.vector(z_emp) positions followed by "n." The nanes need not match the names in the regression table but should capture the same concepts.

for (i in 1:length(nrange)) {
dflist[[i]] <- list()
for (j in 1:trials) {
dflist[[i]][[j]] <- sample_n(pilot_small,size=nrange[i],replace=T)
est <- glm(outcome ~ treatment, data = dflist[[i]][[j]], family = "binomial") %>% summary() # adjust the estimation to be similar to whatever you did in the "test estimation" block of code, just using data=dflist[[i]][[j]] instead of data=pilot
z <- est[["coefficients"]][,3] # you may need to tweak this line if not using glm
results[k,] <- c(as.vector(z),nrange[i])
k <- k +1
}
}

# create vector summarizing each resample as significant (1) or not significant (0)
results\$treatment.stars <- 0
results\$treatment.stars[abs(results\$treatment)>=1.96] <- 1``````

## Interpret results

### Dist of Z by sample size

As an optional first step, plot the distributions of z-scores across resamples by sample size.

``````results %>% ggplot(mapping = aes(x=treatment)) +
geom_density(alpha=0.4) +
theme_classic() +
facet_wrap(~n)``````

### Number of Significant Resamples for Treatment Effect

Next make a table for what you really want to know, which is how often resamples of a given sample size gives you statistical significance. This rate can be interpreted as power.

``table(results\$n,results\$treatment.stars)``
``````##
##         0   1
##   50  355 645
##   60  252 748
##   70  195 805
##   80  137 863
##   90  105 895
##   100  66 934``````

As you can see, n=70 seems to give about 80% power. To confirm this and get a more precise value, you’d probably want to run the script again but this time with `nrange <- c(67,68,69,70,71,72,73)` and `trials <- 10000`.

## Stratified Samples

### 50/50 Strata (Common for RFTs)

Note that you can modify the approach slightly to have stratified resamples. For instance, you might want to ensure an equal number of treatment and outcome cases in each resample to mirror a 50/50 random assignment design. (This should mostly be an issue for relatively small resamples as for large resamples you are likely to get very close to the ratio in the pilot test just by chance.)

To do this we modify the algorithm by first splitting the pilot data into treatment and control data frames and then sampling separately from each before recombining, but otherwise using the same approach as before.

``````pilot_control <- pilot_small %>% filter(treatment==0)
pilot_treatment <- pilot_small %>% filter(treatment==1)

trials_5050 <- 1000 # how many resamples per sample size
nrange_5050 <- c(50,60,70,80,90,100) # values of sample size to test

nrange_5050 <- 2 * round(nrange_5050/2) # ensure all values of nrange are even

dflist_5050 <- list()
k <- 1 # this object keeps track of which row of the results object to write to
results_5050 <- matrix(nrow = length(nrange_5050)*trials_5050, ncol=3) %>% data.frame() #adjust ncol value to be length(as.vector(z_emp))+1
colnames(results_5050) <- c('int','treatment','n') # replace the vector with names for as.vector(z_emp) positions followed by "n." The nanes need not match the names in the regression table but should capture the same concepts.

for (i in 1:length(nrange_5050)) {
dflist_5050[[i]] <- list()
for (j in 1:trials_5050) {
dflist_5050[[i]][[j]] <- rbind(sample_n(pilot_control,size=nrange_5050[i]/2,replace=T),
sample_n(pilot_treatment,size=nrange_5050[i]/2,replace=T))
est <- glm(outcome ~ treatment,
data = dflist_5050[[i]][[j]],
family = "binomial") %>%
summary()
z <- est[["coefficients"]][,3]
results_5050[k,] <- c(as.vector(z),nrange_5050[i])
k <- k +1
}
}

results_5050\$treatment.stars <- 0
results_5050\$treatment.stars[abs(results_5050\$treatment)>=1.96] <- 1``````

### Number of Significant Resamples for Treatment Effect With 50/50 Strata

``table(results_5050\$n,results_5050\$treatment.stars)``
``````##
##         0   1
##   50  330 670
##   60  248 752
##   70  201 799
##   80  141 859
##   90   91 909
##   100  63 937``````

Not surprisingly, our 80% power estimate is still about 70.

### One Fixed Strata and the Other Estimated

Or perhaps you know the size of a sample in one strata and want to test the necessary size of another strata. Perhaps a power analysis for a hypothesis specific to strata one gives n1 as its necessary sample size but you want to estimate a power analysis for a pooled sample where n=n1+n2. Likewise, you may wish to estimate the necessary size of an oversample. Note that if you already have one strata in hand you could modify this code to work but should just use the data for that strata, not resamples of it.

For one fixed and one estimated strata, let’s assume our pilot test is departments A and B from the `UCBAdmissions` file, that we know we need n=500 for 80% power on some hypothesis specific to department A, and we are trying to determine how many we need for department B in order to pool and analyze them together. I specify dummies for gender (male) and a dummy for department A (vs B).

``````ucb_tidy <- UCBAdmissions %>%
as_tibble() %>%
uncount() %>%
mutate(male = (Gender=="Male"),

ucb_A <- ucb_tidy %>% filter(Dept=="A") %>% mutate(depA=1)
ucb_B <- ucb_tidy %>% filter(Dept=="B") %>% mutate(depA=0)

n_A <- 500
trials_B <- 1000 # how many resamples per sample size
nrange_B <- c(50,100,150,200,250,300,350,400,450,500,550,600,650,700,750,800,850,900,950,1000) # values of sample size to test

dflist_B <- list()
k <- 1 # this object keeps track of which row of the results object to write to
results_B <- matrix(nrow = length(nrange_B)*trials_B, ncol=4) %>% data.frame() #adjust ncol value to be length(as.vector(z_emp))+1
colnames(results_B) <- c('int','male','depA','n') # replace the vector with names for as.vector(z_emp) positions followed by "n." The nanes need not match the names in the regression table but should capture the same concepts.

for (i in 1:length(nrange_B)) {
dflist_B[[i]] <- list()
for (j in 1:trials_B) {
dflist_B[[i]][[j]] <- rbind(sample_n(ucb_B,size=nrange_B[i],replace=T),
sample_n(ucb_A,size=n_A,replace=T))
est <- glm(admitted ~ male + depA, data = dflist_B[[i]][[j]], family = "binomial") %>% summary()
z <- est[["coefficients"]][,3]
results_B[k,] <- c(as.vector(z),nrange_B[i])
k <- k +1
}
}

results_B\$male.stars <- 0
results_B\$male.stars[abs(results_B\$male)>=1.96] <- 1``````

### Number of Significant Resamples for Gender Effect With Unbalanced Strata

``table(results_B\$n,results_B\$male.stars)``
``````##
##          0   1
##   50   108 892
##   100  132 868
##   150  128 872
##   200  120 880
##   250  144 856
##   300  133 867
##   350  153 847
##   400  194 806
##   450  181 819
##   500  159 841
##   550  186 814
##   600  168 832
##   650  185 815
##   700  197 803
##   750  201 799
##   800  194 806
##   850  191 809
##   900  209 791
##   950  183 817
##   1000 214 786``````

This reveals a tricky pattern. We see about 90% power when there are either 50 or 100 cases from department B (i.e., 550-600 total including the 500 from department A). With `trials_B <- 1000` it’s a bit noisy but still apparent that the power drops as we add cases from B and then rises again along a U-shaped curve.

Normally you’d expect that more sample size would mean more statistical power because standard error is inversely proportional to the square root of degrees of freedom. The trick is that this assumes nothing happens to β. As it happens, `UCBAdmissions` is a famous example of Simpson’s Paradox and specifically the gender effects are much stronger for department A …

``glm(admitted ~ male, data = ucb_A, family = "binomial") %>% summary()``
``````##
## Call:
## glm(formula = admitted ~ male, family = "binomial", data = ucb_A)
##
## Deviance Residuals:
##     Min       1Q   Median       3Q      Max
## -1.8642  -1.3922   0.9768   0.9768   0.9768
##
## Coefficients:
##             Estimate Std. Error z value Pr(>|z|)
## (Intercept)   1.5442     0.2527   6.110 9.94e-10 ***
## maleTRUE     -1.0521     0.2627  -4.005 6.21e-05 ***
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## (Dispersion parameter for binomial family taken to be 1)
##
##     Null deviance: 1214.7  on 932  degrees of freedom
## Residual deviance: 1195.7  on 931  degrees of freedom
## AIC: 1199.7
##
## Number of Fisher Scoring iterations: 4``````

… than the gender effects are for department B.

``glm(admitted ~ male, data = ucb_B, family = "binomial") %>% summary()``
``````##
## Call:
## glm(formula = admitted ~ male, family = "binomial", data = ucb_B)
##
## Deviance Residuals:
##     Min       1Q   Median       3Q      Max
## -1.5096  -1.4108   0.9607   0.9607   0.9607
##
## Coefficients:
##             Estimate Std. Error z value Pr(>|z|)
## (Intercept)   0.7538     0.4287   1.758   0.0787 .
## maleTRUE     -0.2200     0.4376  -0.503   0.6151
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## (Dispersion parameter for binomial family taken to be 1)
##
##     Null deviance: 769.42  on 584  degrees of freedom
## Residual deviance: 769.16  on 583  degrees of freedom
## AIC: 773.16
##
## Number of Fisher Scoring iterations: 4``````

Specifically, department A strongly prefers to admit women whereas department B has only a weak preference for admitting women. The pooled model has a dummy to account for department A generally being much less selective than department B but it tacitly assumes that the gender effect is the same as it has no interaction effect. This means that as we increase the size of the department B resample, we’re effectively flattening the gender slope through compositional shifts towards department B and its weaker preference for women.